Table 4.
Adjusted mean total hip BMD loss, BMC loss, and area gain by quintile of baseline sex hormone measures
| Sex hormone measure | Total hip BMD loss
|
Total hip BMC loss
|
Total hip area gain
|
|||
|---|---|---|---|---|---|---|
| Loss (%/yr) | P value | Loss (%/yr) | P value | Gain (%/yr) | P value | |
| Total estradiol quintiles | 0.43 | 0.04 | 0.01 | |||
| 1 (<61.3 pmol/liter) | −0.380 | 0.96 | −0.295 | 0.25 | 0.129 | 0.06 |
| 2 (61.3–74.2 pmol/liter) | −0.421 | 0.60 | −0.334 | 0.12 | 0.121 | 0.04 |
| 3 (74.2–87.0 pmol/liter) | −0.267 | 0.18 | −0.140 | 0.83 | 0.188 | 0.32 |
| 4 (87.0–104.6 pmol/liter) | −0.269 | 0.18 | −0.088 | 0.47 | 0.223 | 0.64 |
| 5 (≥104.6 pmol/liter) | −0.369 | Reference | −0.164 | Reference | 0.254 | Reference |
| BioE2 quintiles | 0.03 | 0.009 | 0.14 | |||
| 1 (<39.7 pmol/liter) | −0.472 | 0.05 | −0.371 | 0.02 | 0.134 | 0.11 |
| 2 (39.7–48.1 pmol/liter) | −0.338 | 0.67 | −0.199 | 0.37 | 0.189 | 0.43 |
| 3 (48.1–56.0 pmol/liter) | −0.374 | 0.37 | −0.276 | 0.10 | 0.158 | 0.20 |
| 4 (56.0–66.0 pmol/liter) | −0.235 | 0.45 | −0.081 | 0.85 | 0.190 | 0.44 |
| 5 (≥66.0 pmol/liter) | −0.293 | Reference | −0.101 | Reference | 0.241 | Reference |
| Estrone quintiles | 0.43 | 0.02 | 0.007 | |||
| 1 (<86.2 pmol/liter) | −0.386 | 0.58 | −0.270 | 0.08 | 0.156 | 0.04 |
| 2 (86.2–106.5 pmol/liter) | −0.361 | 0.81 | −0.319 | 0.03 | 0.101 | 0.003 |
| 3 (106.5–127.6 pmol/liter) | −0.322 | 0.93 | −0.209 | 0.20 | 0.150 | 0.03 |
| 4 (127.6–159.1 pmol/liter) | −0.300 | 0.69 | −0.136 | 0.58 | 0.225 | 0.29 |
| 5 (≥159.1 pmol/liter) | −0.324 | Reference | −0.071 | Reference | 0.290 | Reference |
| Total testosterone quintiles | 0.73 | 0.66 | 0.11 | |||
| 1 (<9.81nmol/liter) | −0.338 | 0.90 | −0.227 | 0.57 | 0.152 | 0.26 |
| 2 (9.81–12.17 nmol/liter) | −0.319 | 0.90 | −0.209 | 0.70 | 0.157 | 0.28 |
| 3 (12.17–14.70 nmol/liter) | −0.298 | 0.67 | −0.191 | 0.81 | 0.149 | 0.25 |
| 4 (14.70–18.17 nmol/liter) | −0.405 | 0.38 | −0.222 | 0.59 | 0.234 | 0.82 |
| 5 (≥18.17 nmol/liter) | −0.336 | Reference | −0.165 | Reference | 0.220 | Reference |
| BioT quintiles | 0.17 | 0.21 | 0.45 | |||
| 1 (<5.43 nmol/liter) | −0.427 | 0.07 | −0.347 | 0.04 | 0.123 | 0.12 |
| 2 (5.43–6.56 nmol/liter) | −0.330 | 0.50 | −0.145 | 0.82 | 0.234 | 0.89 |
| 3 (6.56–7.47 nmol/liter) | −0.306 | 0.69 | −0.169 | 0.64 | 0.175 | 0.43 |
| 4 (7.47–8.78 nmol/liter) | −0.371 | 0.21 | −0.262 | 0.16 | 0.149 | 0.23 |
| 5 (≥8.78 nmol/liter) | −0.275 | Reference | −0.117 | Reference | 0.221 | Reference |
| SHBG quintiles | 0.002 | 0.06 | 0.24 | |||
| 1 (<33.3 nmol/liter) | −0.249 | 0.003 | −0.110 | 0.04 | 0.182 | 0.43 |
| 2 (33.3–42.6 nmol/liter) | −0.318 | 0.03 | −0.250 | 0.49 | 0.112 | 0.07 |
| 3 (42.6–50.9 nmol/liter) | −0.220 | 0.001 | −0.049 | 0.01 | 0.218 | 0.84 |
| 4 (50.9–62.9 nmol/liter) | −0.422 | 0.36 | −0.288 | 0.71 | 0.184 | 0.49 |
| 5 (≥62.9 nmol/liter) | −0.516 | Reference | −0.335 | Reference | 0.226 | Reference |
All results adjusted for age, race, clinic, and baseline weight and weight change. P values in bold are P for trend across quintiles of sex steroid hormones. All other P values are pairwise comparisons of each quintile vs. quintile 5.