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. 2010 Jun 9;95(9):E9–E17. doi: 10.1210/jc.2010-0460

Figure 2.

Figure 2

Modulatory effects of resveratrol on the inhibitory effects of estradiol on VSMC proliferation (DNA synthesis and cell number) and collagen synthesis. Top panel depicts the inhibitory effects of 100 nmol/liter of estradiol (β-Est) on 2.5% serum (FCS)-induced DNA synthesis in the presence and absence of low concentrations of resveratrol (Res; 0, 0.1, 1, 2.5, 5, and 10 μmol/liter) and 5 μmol/liter ABT. Middle and bottom panels show the concentration-dependent attenuation by resveratrol (Res) and ABT of the inhibitory effects of estradiol (β-Est; 100 nmol/liter) on collagen synthesis and cell number, respectively. Values represent mean ± sem from at least four independent experiments, each conducted in triplicate. *, P < 0.05 vs. control cells (Cont) treated with FCS or PDGF-BB alone; §, P < 0.05 vs. cells treated with estradiol (significant reversal of the inhibitory effects).