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. 2010 Jun 9;95(9):E9–E17. doi: 10.1210/jc.2010-0460

Figure 3.

Figure 3

A, Abrogation by resveratrol (Res; 5 μmol/liter) and ABT (a broad spectrum CYP450 inhibitor; 5 μmol/liter) on the inhibitory actions of estradiol (β-Est; 1 and 100 nmol/liter) on PDGF-BB (25 ng/ml)-induced VSMC migration. Values represent mean ± sem from at least three independent experiments, each conducted in triplicate. *, P < 0.05 vs. control cells treated with FCS or PDGF-BB alone; §, P < 0.05 vs. cells treated with estradiol (significant reversal of the inhibitory effects). B, Modulatory effects of resveratrol (Res; 5 μmol/liter) on the inhibitory effects 2-hydroxyestradiol (OE; 0.1 μmol/liter) and 2-methoxyoestradiol (ME; 0.1 μmol/liter) on 2.5% serum (FCS)-induced DNA synthesis and collagen synthesis. Values represent mean ± sem from at least three independent experiments, each conducted in triplicate. *, P < 0.05 vs. control (VSMCs treated with FCS alone).