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. 2010 Jun 9;95(9):E9–E17. doi: 10.1210/jc.2010-0460

Figure 6.

Figure 6

A, Modulatory effects of resveratrol (Resv; 5 μmol/liter) on the growth-modulatory effects of ER-α and ER-β agonists PPT (100 nmol/liter) and diarylpropionitrile (DPN; 10nmol/liter), respectively, on 2.5% FCS-induced DNA synthesis. Values represent mean ± sem from at least three independent experiments, each conducted in triplicate. *, P < 0.05 vs. control (VSMCs treated with FCS alone); §, P < 0.05 vs. PPT (significant reversal of the inhibitory effects). Cont, Control. B, Modulatory effects of PPARγ antagonist (GW; 5 μmol/liter) on the inhibitory effects of high concentrations of resveratrol (10, 25, and 50 μmol/liter) on 2.5% FCS-induced VSMC growth (DNA synthesis). C, Modulatory effects of ER antagonist (ICI; 10 μmol/liter) and PPARγ antagonist (GW; 5 μmol/liter) on the inhibitory effects of high concentrations of resveratrol (Res; 50 μmol/liter) and resveratrol (10, 25, and 50 μmol/liter) plus estradiol (Est; 10 nmol/liter) on 2.5% FCS-induced VSMC growth (DNA synthesis). Values represent mean ± sem from at least four independent experiments, each conducted in triplicate. Con, Control. *, P < 0.05 vs. control (VSMCs treated with FCS alone); §, P < 0.05 vs. resveratrol alone (significant reversal of the inhibitory effects).