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Estradiol replacement in ovariectomized mice achieves physiological levels of 17β-estradiol in serum. Physiological estradiol replacement in mice (n = 4 per group) produces serum levels that are equivalent to basal circulating levels in the mouse estrous cycle. The low range of sensitivity of the radioimmunoassay was determined to be approximately 5.0 pg/ml. Values represent mean ± SEM.
