Table 1.
Expression and distribution of angiogenic molecules in HCC tissue arrays
| HC | AT | HCC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (-) | (+) | (++) | Positive Percent | (-) | (+) | (++) | Positive Percent | (-) | (+) | (++) | Positive Percent | |
| VEGF-A | 35 | 3 | 6 | 20.5% | 43 | 9 | 46 | 56.1%** | 41 | 29 | 27 | 57.7%^^## |
| bFGF | 27 | 4 | 13 | 38.6% | 29 | 13 | 55 | 70.1%** | 32 | 41 | 23 | 66.7%^^## |
| TGF-β | 20 | 8 | 16 | 54.5% | 11 | 4 | 83 | 88.8%** | 14 | 15 | 68 | 85.6%^^# |
| MCP-1 | 20 | 8 | 8 | 44.4% | 32 | 21 | 44 | 67.0%* | 59 | 21 | 17 | 39.2%## |
| TSP-1 | 38 | 4 | 1 | 11.6% | 43 | 14 | 41 | 56.1%** | 37 | 33 | 27 | 61.9%^^## |
| MMP-9 | 28 | 7 | 9 | 36.4% | 25 | 13 | 59 | 74.2%** | 40 | 23 | 35 | 59.2%^## |
| TIMP-1 | 24 | 2 | 13 | 38.5% | 63 | 14 | 17 | 33.0% | 69 | 10 | 17 | 28.1% |
| TIMP-2 | 21 | 6 | 17 | 52.3% | 19 | 13 | 66 | 80.6%** | 26 | 37 | 35 | 73.5%^^## |
| Endostatin | 23 | 9 | 10 | 45.2% | 14 | 9 | 75 | 85.7%** | 37 | 21 | 40 | 62.2%## |
| COX-2 | 25 | 9 | 10 | 43.2% | 7 | 39 | 51 | 92.8%** | 9 | 46 | 43 | 90.8%^^ |
| NOS-2 | 32 | 9 | 3 | 27.3% | 37 | 21 | 40 | 62.2%** | 43 | 30 | 25 | 56.1%^^ |
*p < 0.05, **p < 0.01, AT versus HC; #p < 0.05, ##p < 0.01, HCC versus AT, ^p < 0.05; ^^p < 0.01, HCC versus HC