Table 3.
IL-10 polymorphisms and risk of PCa
| Genotype/Allele/haplotype | Controls n (%) | PCa n (%) | P | Adjusted OR* (95%CI) |
|---|---|---|---|---|
| Genotype(-1082A/G) | ||||
| AA | 240(88.9) | 222(84.7) | 1.00 | |
| AG | 27(10.0) | 36(13.7) | 0.141 | 1.50(0.87~2.57) |
| GG | 3(1.1) | 4(1.5) | 0.520 | 1.68(0.35~8.17) |
| Allele | ||||
| A | 507(93.9) | 480(91.6) | 1.00 | |
| G | 33(6.1) | 44(8.4) | 0.113 | 1.48(0.91~2.38) |
| Genotype(-819 C/T) | ||||
| TT | 132(48.9) | 120(45.9) | 1.00 | |
| TC | 110(40.7) | 108(41.2) | 0.675 | 1.08(0.75~1.56) |
| CC | 28(10.4) | 34(12.9) | 0.296 | 1.35(0.77~2.36) |
| Allele | ||||
| T | 374(69.3) | 348(66.4) | 1.00 | |
| C | 166(30.7) | 176(33.6) | 0.309 | 1.14(0.88~1.48) |
| Genotype(-592 C/A) | ||||
| AA | 132(48.8) | 120(45.9) | 1.00 | |
| AC | 110(40.8) | 108(41.2) | 0.675 | 1.08(0.75~1.56) |
| CC | 28(10.4) | 34(12.9) | 0.296 | 1.35(0.77~2.36) |
| Allele | ||||
| A | 374(69.3) | 348(66.4) | 1.00 | |
| C | 166(30.7) | 176(33.6) | 0.309 | 1.14(0.88~1.48) |
| Haplotype | ||||
| ATA | 368(68.1) | 340(64.9) | 1.00 | |
| ACC | 139(25.7) | 140(26.7) | 0.551 | 1.13(0.86~1.47) |
| GTA | 6(1.1) | 8(1.5) | 0.489 | 1.42(0.56~4.12) |
| GCC | 27(5.0) | 36(6.9) | 0.174 | 1.45(0.86~2.47) |
OR*, adjusted for age and smoking status