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The effect of FLLL32 on human protein and lipid kinases using a kinase profile assay.
| Protein Kinases | IC50 (μM) | |
|---|---|---|
| Tyrosine kinases contain SH2 Domain | JAK3 | >100 |
| Lck | >100 | |
| Syk | >100 | |
| ZAP-70 | >100 | |
| TYK2 | >100 | |
| Tyrosine kinases containSH2 and SH3 Domains | Abl-1 | >100 |
| BTK | >100 | |
| Lyn | >100 | |
| Yes | >100 | |
| Other human protein or lipid kinases | AKT1 | >100 |
| CDK4/CyclinD1 | >100 | |
| FAK | >100 | |
| JNK1-α1 | >100 | |
| MEK1 | >100 | |
| mTOR | >100 | |
| PI3K (P110α/85α) | 63.23 | |
| PI3K (P110β/85α) | 57.33 | |
| PKA | >100 | |
| PKCα | >100 | |
| PKC-γ | >100 | |
