Table 3.
IC50 values (μM) of FLLL32, curcumin, and other JAK2/STAT3 or STAT3 SH2 inhibitors in human colorectal cancer cells (C), glioblastoma cells (G), multiple myeloma (MM) and liver (L) cancer cells.
| FLLL32 | WP1066 | Stattic | S3I-201 | AG490 | Curcumin | |
|---|---|---|---|---|---|---|
| SW480 (C) | 0.38 | 1.98 | 0.43 | >100 | 86.8 | 10.26 |
| HCT-116 (C) | 0.32 | 1.51 | 0.96 | >100 | 50.5 | 10.91 |
| U87 (G) | 0.19 | 5.78 | 0.73 | 55.10 | >100 | 6.91 |
| U251 (G) | 0.26 | 5.04 | 0.84 | 97.30 | 50.70 | 7.10 |
| U266 (MM) | 0.48 | 1.38 | 0.99 | 8.87 | 9.50 | 4.76 |
| ARH77 (MM) | 2.34 | 3.43 | 2.57 | 35.25 | 28.20 | 10.13 |
| SNU-449 (L) | 2.04 | 3.85 | 2.50 | >100 | >100 | 9.88 |
| SNU-398 (L) | 0.65 | 4.88 | 3.23 | 16.20 | 24.30 | 5.37 |
| Hep3B (L) | 2.31 | 10.20 | 17.78 | >100 | >100 | 68.12 |
| SNU-387 (L) | 2.89 | 5.17 | 4.30 | >100 | >100 | 25.54 |