Alterations (mean ± SEM) in sucrose (A), chow
(B), or water (C) intake across a range
(0.0001–20%) of sucrose concentrations in WT (dark circles), PPEKO
(open squares), and HZ (closed squares) mice. As expected, significant
increases in sucrose intake [ANOVA, F(8,48) =
334.38; Tukey's t test, P <
0.0001] and significant decreases in chow (F =
319.57, P < 0.0001) and water
(F = 47.47, P < 0.0001)
intakes were observed as a function of sucrose concentration. However,
the patterns of each of the three types of intake across the sucrose
concentrations failed to differ among genotypes [sucrose,
F(2,30) = 2.76, P < 0.07;
chow, F = 2.71, P < 0.083;
water, F = 2.44, n.s.]. Although the second squad
of animals consumed significantly more sucrose
[F(2,12) = 29.42, P <
0.0001] and chow (F = 4.12, P
< 0.044) and drank significantly less water (F =
27.71, P < 0.0001) than the first and third
squads, these effects occurred consistently over all genotypes and
failed to alter the genotype results.