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. 2010 Aug 23;11:435. doi: 10.1186/1471-2105-11-435

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Copyright ©2010 Friard et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Example of CircuitsDB usage. Graphical snapshots of a typical working session with CircuitsDB. a) In the first step the user selects an organism of interest and at least one search key among the available ones: Transcription Factor (TF) or microRNA (miRNA) or Joint Target gene name. b) In the second panel a list of mixed TF/miRNA regulatory circuits is retrieved. c) In the third panel an example of CircuitsDB output is shown: a single mixed Feed-Forward Loop is identified and its components are reported in a tabular-like fashion. The user can explore TF additional information, as well as miRNA and Joint Target annotations. A sequence analysis panel and a Wiki for community feedback are available. d) Example of sequence analysis panel: TF binding sites are explicitly highlighted on the miRNA core promoter region.