Figure 1.

TCR-Ig fusion protein formats. In TCRV-IgC molecules, the Ig V regions are replaced by TCR V regions (A). cTCR-cIg molecules have the complete extracellular part of a TCR, C+V domains (cTCR) fused N terminally to a complete Ig (cIg) (B). In cTCR-IgFc molecules, the extracellular part of the TCR is fused to an Ig Fc region. TCR domains are filled and Ig domains are open circles (C). Notably, both the α and the β portions were tested as fusions to both the heavy and the light Ig chains in the TCRV-IgC (A) and cTCR-cIg (B) versions.