Table 1.
Clinical and management characteristics of the study patients and analysis of features associated with an excessively lengthy treatment.
| Feature | Treatment duration | Statistical analyses | ||||||
|---|---|---|---|---|---|---|---|---|
|
All patients N = 478 |
According to guidelines N = 316 |
Excessive duration N = 162 |
Univariate analysis |
Multivariate analysis |
||||
|
Number of patients |
Median duration [IQR] |
Odds Ratio [95%CI] |
P value |
Odds Ratio [95%CI] |
P value | |||
| Clinical characteristics | ||||||||
| Previous TB | 53 (11.1%) | 22 (7.0%) | 31 (19.1%) | 315 [252-387] | 3.0 [1.8-5.8] | <0.0001 | 2.9 [1.6-5.4] | 0.001 |
| Isolated thoracic TB | 279 (58.4%) | 172 (54.4%) | 107 (66.0%) | 275 [250-311] | 1.6 [1.1-2.4] | 0.02 | 2.2 [1.4-3.5] | <0.0001 |
| HIV seropositivity | 74 (16.9%) | 36 (11.4%) | 38 (23.5%) | 361 [289-418] | 2.3 [1.4-3.8] | 0.001 | 2.5 [1.4-4.4] | 0.002 |
| Alcoholism | 83 (19.4%) | 42 (13.3%) | 41 (25.3%) | 287 [266-367] | 2.0 [1.2-3.3] | 0.004*** | - | - |
| Injecting drug use | 10 (2.1%) | 02 (0.6%) | 08 (4.9%) | 352 [305-419] | 7.5 [1.6-35.8] | 0.01*** | - | - |
| Psychiatric disorders | 38 (7.9%) | 23 (7.3%) | 15 (9.3%) | 321 [274-367] | 1.2 [0.6-2.3] | 0.62 | ||
| Precarious situation* | 210 (43.9%) | 137 (43.4%) | 73 (45.1%) | 292 [274-407] | 1.0 [0.7-1.5] | 0.98 | ||
| Isoniazid resistance | 27 (5.6%) | 17 (5.4%) | 10 (6.2%) | 273 [241-396] | 1.1[0.5-2.6] | 0.72 | ||
| Management modalities | ||||||||
| Prescriber | 0.002 | 0.01 | ||||||
| Chest specialist | 211 (44.1) | 157 (49.7%) | 54 (33.3%) | 274 [265-315] | 1 (reference) | 1 (reference) | ||
| Infectious disease specialist | 171 (35.8%) | 98 (31.0%) | 73 (45.1%) | 354 [274-427] | 2.2 [1.4-3.3] | 2.1 [1.3-3.4] | ||
| Other | 96 (20.1%) | 61 (19.3%) | 35 (21.6%) | 379 [287-498] | 1.7 [1.0-2.8] | 1.9 [1.1-3.3] | ||
| Number of institutions per patient | 0.01 | 0.001 | ||||||
| 1 | 295 (61.7%) | 210 (66.7%) | 85 (52.8%) | 282 [257-375] | 1 (reference) | 1 (reference) | ||
| 2 | 152 (31.8%) | 93 (29.5%) | 59 (36.6%) | 366 [274-448] | 1.6 [1.0-2.4] | 1.7 [1.1-2.7] | ||
| ≥3 | 29 (6.5%) | 12 (3.8%) | 17 (10.6%) | 356 [292-471] | 3.5 [1.6-7.6] | 4.3 [1.9-10.1] | ||
| Place of follow-up** | 0.07*** | - | ||||||
| University hospital | 423 (88.5%) | 274 (86.7%) | 149 (92.0%) | 332 [271-431] | 1 (reference) | |||
| Welfare centers or other | 55 (11.5%) | 42 (13.3%) | 13 (8.0%) | 276 [273-288] | 1.7 [0.9-3.4] | |||
| Directly Observed Therapy | 32 (6.7%) | 16 (5.1%) | 16 (9.9%) | 292 [275-352] | 2.0 [1.0-4.2] | 0.06*** | - | - |
| Computerized follow-up | 145 (30.3%) | 104 (34.2%) | 41 (25.3%) | 294 [274-367] | 0.7 [0.4-1.0] | 0.08*** | - | - |
*Poor living conditions and/or no health insurance
**Main structure used by each patient
***Non significant variables in the multivariate analysis