FIG. 3.

Comparison of V_d:V_i ratios with repeated brainstem and thalamic infusions. Initial V_d:V_i delivery parameters during Gd-only infusions (solid squares, n = 5; mean V_d:V_i ratio, 3.74 ± 0.25; R² = 0.96) were replicated in later infusions consisting of AAV2-hASM-HA/Gd (open squares, n = 5; mean V_d:V_i ratio, 3.72 ± 0.24; R² = 0.98). Note the consistent distribution patterns in consecutive infusions with or without therapeutic agent (overall, n = 10, R² = 0.96). No significant difference was found between primary and secondary infusions (p > 0.05).