Table 2.
Distribution Area (Gadoteridol) and Transgene Expression in Brainstem and Thalamus
Brainstem | NHP | Gd (cm2) | Histology (cm2) | Percentage (%) |
---|---|---|---|---|
843 | 0.81 | 0.93 | 115 | |
1210 | 0.65 | 0.88 | 135 | |
1260 | 0.98 | 0.98 | 100 | |
1228 | 0.79 | 0.92 | 116 | |
Mean + SEM: | 117 ± 7.2% |
Thalamus | NHP (L/R side) | Gd (cm2) | Histology (cm2) | Percentage (%) |
---|---|---|---|---|
843 (L) | 0.82 | 0.88 | 107 | |
1210 (L) | 0.21 | 0.20 | 94 | |
1260 (L) | 0.39 | 0.28 | 71 | |
1228 (L) | 0.41 | 0.19 | 45 | |
843 (R) | 0.36 | 0.36 | 100 | |
1210 (R) | 0.25 | 0.23 | 92 | |
1228 (R) | 0.54 | 0.36 | 66 | |
Mean + SEM: | 82 ± 8.4% |
Abbreviations: Gd, gadoteridol; L, left; NHP, nonhuman primate; R, right.