Table 1. Top SNP effect GWA hits for 12 phenotypes.
| Trait | Cytoband | Gene(s) | Top SNP, Alleles | #SNPs @ P<10−5 | Risk AF | Beta (SE) | P |
| diastolic BP | 5p13.3 | CDH9/CDH6 | rs7704530 G/A | 2/3 | 0.26 | 8.44 (1.57) | 1.1×10−7 |
| diastolic BP | 7q11.21 | TPST1 | rs709595 C/G | 8/17 | 0.39 | 7.18 (1.43) | 7.0×10−7 |
| glucose | 2q24.3 | G6PC2, ABCB11 | rs853773 A/G | 4/1 | 0.53 | −8.72 (1.73) | 7.0×10−7 |
| glucose | 6q22.31 | NKAIN2/RNF217 | rs781718* G/A | 1/4 | 0.89 | −3.46 (0.69) | 8.4×10−7 |
| HDL-cholesterol | 16q12.2 | HERPUD1/CETP | rs247616* T/C | 4/2 | 0.33 | 3.77 (0.75) | 6.6×10−7 |
| insulin | 7p14.3 | CHN2 | rs3793275* A/T | 1/3 | 0.94 | −4.63 (0.78) | 5.8×10−9 |
| insulin | 20p13 | RNF24/SMOX | rs6052399* T/C | 0/1 | 0.93 | −4.55 (0.84) | 9.8×10−8 |
| insulin | 6q14.1 | BCKDHB/FAM46A | rs16892328* C/T | 0/1 | 0.94 | −4.93 (0.92) | 1.3×10−7 |
| insulin | 18p11.31 | MRLC2/TGIF1 | rs1613695* G/A | 0/1 | 0.95 | −5.68 (1.07) | 1.7×10−7 |
| insulin | 14q13.3 | TTC6/SSTR1 | rs10498337 T/G | 1/0 | 0.81 | −9.3 (1.87) | 8.9×10−7 |
| LDL-cholesterol | 21q22.11 | MRPS6/KCNE2 | rs8131349* A/G | 0/1 | 0.06 | 17.6 (3.05) | 1.4×10−8 |
| LDL-cholesterol | 19q13.33 | APOE/APOC1 | rs7412 T/C | 1/1 | 0.07 | −69.74 (12.15) | 1.6×10−8 |
| LDL-cholesterol | 6q22.31 | C6orf170/GJA1 | rs7738656 G/A | 1/0 | 0.84 | −42.39 (8.11) | 2.5×10−7 |
| LDL-cholesterol | 5q33.2 | KIF4B/SGCD | rs10044666* G/T | 1/3 | 0.72 | −8.57 (1.68) | 4.7×10−7 |
| systolic BP | 11q24.1 | ASAM/GRAMD1B | rs11822822 G/A | 2/4 | 0.24 | 10.74 (2.12) | 5.6×10−7 |
| systolic BP | 15q22.1 | RORA/VPS13C | rs726914 G/A | 2/0 | 0.62 | 9.21 (1.83) | 7.1×10−7 |
| total cholesterol | 21q22.11 | MRPS6/KCNE2 | rs8131349* A/G | 2/2 | 0.06 | 18.4 (3.32) | 4.6×10−8 |
| total cholesterol | 4p16.1 | ABLIM2 | rs6829649 T/G | 1/2 | 0.87 | −50.96 (9.42) | 9.6×10−8 |
| total cholesterol | 6q22.31 | C6orf170/GJA1 | rs7738656 G/A | 1/1 | 0.84 | −46.21 (8.79) | 2.1×10−7 |
| total cholesterol | 8q24.22 | ST3GAL1/ZFAT | rs4897695* C/G | 1/6 | 0.91 | 13.66 (2.62) | 2.7×10−7 |
| waist circumference | 8q24.13 | MTSS1/ZNF572 | rs891541* A/G | 4/7 | 0.29 | 4.55 (0.91) | 7.7×10−7 |
A list of all SNP effect P-values less than 10−6 in the BHS. SNP names marked with an “*” are imputed, while those that are unmarked are directly genotyped. SNP alleles are reported as risk/nonrisk and are in genome forward orientation (build 36.3). The number of SNPs @ P<10−5 corresponds to the number of genotyped/imputed SNPs with P<10−5 within 200kb up and downstream of the top SNP. Associations at P<5×10−8 are indicated in bold.