Table 2. Nucleotide contents of clonal pathogens with intermediate and high GC contents are far from equilibrium.
| Clonal pathogen | Current GC content | Sites | #GC→AT a | #AT→GC a |
| MTBC | High | Synonymous | 103 (84, 123) | 18 (10, 26) |
| MTBC | High | Non- synonymous | 127 (105, 151) | 58 (43, 73) |
| B. mallei | High | Synonymous | 45 (33, 59) | 2 (0, 5) |
| B. mallei | High | Non-synonymous | 57 (42, 73) | 7 (2, 12) |
| B. mallei | High | Intergenic | 27 (17, 38) | 12 (6, 19) |
| Y. pestis | Intermediate | Synonymous | 116 (95, 138) | 37 (26, 48) |
| Y. pestis | Intermediate | Non-synonymous | 230 (201, 259) | 79 (63, 97) |
| Y. pestis | Intermediate | Intergenic | 69 (52, 85) | 36 (25, 47) |
| B. anthracis | Low | Synonymous | 44 (32, 57) | 64 (49, 79) |
| B. anthracis | Low | Non-synonymous | 136 (114, 158) | 75 (58, 93) |
| B. anthracis | Low | Intergenic | 141 (119, 166) | 151 (128, 175) |
| S. typhi | Intermediate | Synonymous | 570 (524, 619) | 79 (62, 97) |
| S. typhi | Intermediate | Non-synonymous | 707 (654, 760) | 220 (192, 248) |
| S. typhi | Intermediate | Intergenic | 189 (164, 215) | 65 (50, 81) |
a
95% Confidence intervals appear in parenthesis. Numbers appear in bold if there is a statistically significant (p<0.05) difference between number of GC→AT and number of AT→GC changes.