Figure 1. Phylogenetic tree based on the LBD region of putative LGIC genes.

NJ tree (clustalw) from the LBD region of conceptually translated putative LGIC genes as detected with Genewise after an initial Blast screen with the 210 seeds (see Materials and Methods) - 1426 sequences in total. Thousand bootstrap iterations were performed and branches below 50% bootstrap support were collapsed. Nematode sequences are shown in shades of green, platyhelminthes yellow, insect purple and vertebrate red. Some C. elegans and human subunits are labelled, and the labels for proteins involved in drug susceptibility are coloured: levamisole - cyan, monepantel - orange and ivermectin – blue. Green asterisks indicate branches that similar to these latter appear broad and nematode specific and could be attractive for further investigation as targets for other compounds.