Figure 3. Sensitivity to AAD-1566 determined in vitro.

The percentage of the average number of adult worms present after 3 days exposure relative to a control is plotted versus drug concentration for Caenorhabditis elegans, mutated C. elegans strain acr-23 (cb27), C. japonica, C. briggsae, C. remanei, C. brenneri, Pristionchus pacificus and S. ratti. Sigmoid dose-response curve fit was performed in Prism. EC₅₀ values with standard errors, estimated from data points with four replicates, are shown inset.