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. 2010 Aug 23;107(36):15904–15909. doi: 10.1073/pnas.1010741107

Fig. 1.

Fig. 1.

Schematic representation of the functional domains of wild-type and dominant-negative REST and of the insertion control sequences inserted into the wild-type viral genome. Line 1: arrangement of REST drawn according to ref. 10. Line 2: DNA sequence arrangement of HSV-1 DNA. Line 3: schematic representation of wild-type REST flanked by the SV40 promoter and poly(A) sequence. Line 4: schematic representation of the dominant-negative REST shown lacking the repressor domains and N and C termini. Line 5: sequence arrangement of the insertion control sequence consisting of four stop codons, flanked by the SV40 promoter and poly(A) sequence. All constructs were inserted between UL3 and UL4 genes. NLS, nuclear localization signal.