Fig. 4.

Association of NBCe1 mutations and migraine. (A) Topology of NBCe1 and mutations identified in pRTA patients. Red circles denote mutations associated with migraine and white circles mutations not associated with migraine. The dashed lines represent the specific regions of NBCe1B or NBCe1C, and the N and C denote the N and C terminus, respectively. (B) Confocal images of GFP-tagged wild-type NBCe1B (WT) and the mutants transiently expressed in C6 cells. Asterisks indicate mutations associated with migraine. (Scale bar, 10 μm.)