Table II.

Demographic Characteristics of Genotyped Individuals by Group and Genotype

	Group
	Relatives of SC Patients			Relatives of BPD Patients			Nonpsychiatric Controls
	Val/Val	Val/Met	Met/Met	Val/Val	Val/Met	Met/Met	Val/Val	Val/Met	Met/Met
N	22	41	18	6	20	12	9	13	8
Mean Age (SD)	53(9)a	48(10)	49(12)b	51(10)b	51(20)	45(15)	36(13)	44(9)	34(13)
% Female	71	60	64	83	47	36	44	69	25
% Siblings	64	73	83	50	35	50	n/a	n/a	n/a
% Parents	36	24	11	50	40	33	n/a	n/a	n/a
% Offspring	0	2	6	0	25	17	n/a	n/a	n/a
%Lifetime DSM Axis I Dis.	32	37	33	67	40	50	0	0	0
% Major Depression	23	29	33	67	20	50	0	0	0
% Alcohol Dependence	4	5	11	0	0	0	0	0	0
% Bipolar Disorder	0	2	0	0	0	0	0	0	0
% Anxiety Disorder1	4	7	0	17	15	17	0	0	0
% Lifetime DSM Axis II Dis2.	24	0	0	0	0	22	0	0	0
% Lifetime SCZ Spect. Dis.	24	3	0	0	6	0	0	0	0

Note SC = Schizophrenia or schizoaffective disorder; BPD = Bipolar disorder; DSM = Diagnostic and Statistical Manual; Dis = Disorder ; SCZ Spect. Dis. = DSM-IV Psychotic Disorders and Cluster A Personality Disorders; n/a = not applicable

^ap < .005; compared with controls of same genotype.

^bp < .05; compared with controls of same genotype.

¹Two individuals in the nonpsychiatric control group were given a diagnosis of a lifetime anxiety disorder (one had Panic Disorder, and one had a history of PTSD) but neither of these controls were genotyped.

²Axis II disorders were not assessed for 22 relatives of schizophrenia patients and 13 relatives of bipolar disorder patients because they did not travel to the study site. The percentages reflect the proportion of individuals with genotype data affected for whom Axis II diagnoses were available.