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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Cancer Res. 2010 Jul 22;70(17):6957–6967. doi: 10.1158/0008-5472.CAN-10-1169

Figure 2.

Figure 2

Nav1.5 contributes to invasive potential of colon cancer cells (A) The total number of invading SW620, SW480 and HT29 colon cancer cells was significantly reduced with 30 μM TTX compared to vehicle control. (B) siRNA-mediated knockdown of SCN5A significantly reduced invasion potential of colon cancer cells compared to cells treated with a nonsense siRNA used as a control. Results are means ± SEM from at least three independent experiments *Significantly different from control (two-sided, unpaired t-Test, P < 0.05).