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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Cancer Res. 2010 Jul 22;70(17):6957–6967. doi: 10.1158/0008-5472.CAN-10-1169

Figure 5.

Figure 5

Network interactions predicted from E-gene expression under S-gene knockdown. (A) Expression values of selected E-genes. Each row shows the log-ratio expression of a single E-gene under various targeted siRNA-mediated knockdowns relative to a nonsense siRNA control. (B) Inferred S-gene network and Frontier. Nodes represent S-genes (ovals), E-genes (gray boxes), and Gene Ontology categories (white boxes). Arrows indicate activation, and tees indicate repression. Mixed arrow/tee line endings indicate GO set enrichment among both activated and inhibited E-genes. For simplicity only direct interactions are shown. (C) S-gene interaction confidence. Each pixel in the heatmap corresponds to the proportion of times an S-gene interaction was recovered across bootstrap iterations. Upstream S-genes are labeled on the right; downstream on the top. Rows show upstream and columns show downstream bootstrap proportion.