Fos-immunoreactive nuclei in rats after exposure to the cocaine
S+, S−, and S+ preceded by
administration of SCH 39166 (S+SCH) in the
immediate (a and c) and 4-month delayed
(b and d) tests. Compared with the
S− control condition, the number of Fos-immunoreactive
nuclei was significantly increased after exposure to the cocaine
S+ in the basolateral amygdala and medial prefrontal cortex
(see also caption of Fig. 3), both in the immediate and delayed testing
conditions. SCH 39166 reversed the effects of the cocaine
S+ on Fos expression. *, P <
0.05; **, P < 0.01 (different from
the S− condition). †, P < 0.05, ‡,
P < 0.01 (different from the S+
condition).