Table 1.
Olfactomedin domain-containing genes and their main properties
| Gene | Other names | Chromo some |
Known protein forms |
Main expression sites |
Interacting partners | Affected pathways/phenotypes |
|---|---|---|---|---|---|---|
| OLFM1 | Olfactomedin1, Noelin1, pancortin, hOlfA, AMY |
9q34.3 | 125 aa, 135 aa, 457 aa, 485 aa |
Cortex, hippocampus, retina |
Wave1, dysntrobrevin, Wif-1, Bcl-xL, DISC1*, lectin |
Eye determination, axon growth and branching, apoptosis, Wnt signaling, neurogenesis (Xenopus), neural crest formation (chicken) |
| OLFM2 | olfactomedin2, Noelin2, OlfC |
19p13.2 | 454 aa** | CNS, retina, pharyngeal arches |
Glaucoma | |
| OLFM3 | Olfactomedin3, Optimedin |
1p21.2 | 458 aa, 478 aa |
CNS, retina | Myocilin | Cell adhesion, cytoskeleton organization |
| OLFM4 | Olfactomedin4, GW112, hGC-1, pDP4, hOlfd, olfactoimedin, Tiarin |
13q14.3 | 510 aa | Prostate, small intestine, colon, bone marrow |
GRIM-19, cadherin, lectins |
Cell prolifieration, itestinal stem cell marker, dorsalization of neural tube (Xenopus) |
| OLFML1 | Olfactomedin- like1, ONT2 |
11p15.4 | 402 aa | Small intestine, liver, lung, heart, spleen |
Cell proliferation | |
| OLFML2a | Olfactomedin- like2A, Photomedin-1 |
9q33.3 | 652 aa | Lung, eye, testis, uterus |
Heparin, chondroitin sulfate-E |
|
| OLFML2b | Olfactomedin- like2B, Photomedin-2 |
1q23.3 | 750 aa | Broad spectrum of tissues |
Heparin, chondroitin sulfate-E |
|
| OLFML3 | Olfactomedin- like3, hOLF44, HNOEL-iso, ONT1? |
1p13.2 | 406 aa | Placenta, liver, heart, sclera, iris |
Chordin, BMP1/Tolloid-class proteinase |
Dorsal-ventral patterning (Xenopus) |
| MYOC | Myocilin, TIGR, GLC1A, JOAG1 |
1q23- q24 |
504 aa | trabecular meshwork, sclera, sciatic nerve, retinal pigmented epithelium |
Fibrilin 1, fibronectin 1, flotillin, Olfm3, myosin light chain, hevin |
Glaucoma, Wnt signaling |
| GLDN | Gliomedin, CRG- L2, collomin, colmendin (C. elegans) |
15q21.2 | 551 aa | spinal cord, brain, sciatic nerve |
NrCAM, neurofascin | Nodes of Ranvier formation |
| Lphn1 | Latrophilin1, Lectomedin2, CL1, CIRL1 |
19p13.2 | 1459 aa | CNS | latrotoxin, syntaxin, SHANK2, lectins, synaptotagmin-3, SAP102, PSD95, ANKS1A |
Exocytosis from neurons |
| Lphn2 | Latrophilin2, Lectomedin1, CL2, CIRL2, LPHH1 |
1p31.1 | 1403 aa | Ubiquitous, CNS |
latrotoxin, lectins, SHANK2, synaptotagmin-3 |
Exocytosis from neuroins and neuroendocrine cells |
| Lphn3 | Latrophilin3, Lectomedin3, CIRL3 |
4q13.1 | 1240 aa | CNS | latrotoxin |
*
Interaction of Olfm1 and DISC1 was shown only by yeast two-hybrid screen.
**
Three protein forms (478 aa, 456 aa and 448 aa) were reported for mouse Olfm2.