Table 1.
Non-lamin structural proteins in nucleus and their partners and functions.
| Structural Protein |
Associated Protein | Associated Function |
|---|---|---|
| actin |
CH doamin proteins: αII-spectrin, α actinin-4, βII-spectrin, filamin A, Dystrophin, vav, nesprin-2, L-plastin; Chromatin remodleing complexes: BAF, SWI-SNF, BAP, NuA4, TIP60, PBAF, p400, SWR1, INO80 complexes; Ribonucleoprotein complexes proteins: hrp36, hrp65, DBP40; Other proteins: emerin, titin, protein 4.1, lamin A, MAL, profilin, capG, exportin-6, Zyxin, Myopodin, Nrf2, NDHII, DNase I. |
Nucleoskeleton, Chromatin remodleing, RNA transcription and processing, Nuclear export |
| αII- spectrin |
Structural proteins: actin, protein 4.1, βSpIVΣ5, lamin A, emerin; DNA repair proteins: hHR23B, XPA, RPA32, RPA70, XPB, XPD, XPG, XPF, ERCC1, MRE11, RAD50, RAD51, XRCC2, Ku70,Ku80; Chromatin remodeling proteins: actin, FANCA, BRG1, hBRM, CSB; Fanconi anemia proteins: FANCA, FANCC FANCD2, FANCF, FANCG, FANCJ; Transcription and RNA processing proteins: p40, PML (hnRNP) A2/B1. |
DNA repair, Fanconi Anemia, Nucleoskeleton |
| titin | lamin A, lamin B, actin, nuclear myosin I | Spindle matrix |
| nesprin | lamin A, lamin B, actin, emerin, SUN proteins | LINC complex |
| protein 4.1 | actin, αII-spectrin, NuMA, U2AF, SC35 | Nucleoskeleton, pre- mRNA processing |
| NuMA | Dynein, dynactin, protein 4.1, lamins, Arp1, GAS41, INI1, LGN, tubulin |
Nucleoskeleton, Spindle matrix |
| EAST | actin, CP60, megator, | Endonucleoskeleton |
| megator | EAST | Spindle matrix |
| skeletor | chromator | Spindle matrix |
| chromator | skeletor | Spindle matrix |