TABLE 1.
Effect of apo(a) and apoB expression on plasma biochemical parameters
| Genotype | WT | Apo(a) | ApoB | Lp(a) |
|---|---|---|---|---|
| Female mice |
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| Number of mice | 15 | 10 | 12 | 7 |
| Creatinine (µmol/l) | 23.1 ± 2.0 | 24.3 ± 1.5 | 23.5 ± 2.7 | 25.7 ± 1.9 |
| Urea (mmol/l) | 20.6 ± 2.4 | 19.1 ± 1.9 | 24.4 ± 4.7 | 19.0 ± 3.1 |
| ALAT (U/l) | 40.5 ± 7.3 | 42.7 ± 6.7 | 51.8 ± 8.5 | 66.9 ± 27.7 |
| Alkaline phosphatase (U/l) | 117.6 ± 9.3 | 110.3 ± 13.4 | 144.3 ± 16.7 | 141.4 ± 15.9 |
| Triglycerides (mmol/l) | 0.53 ± 0.04 | 0.63 ± 0.07 | 0.78 ± 0.07a | 0.87 ± 0.11a |
| Male mice |
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| Number of mice | 6 | 9 | 8 | 8 |
| Creatinine (µmol/l) | 18.6 ± 3.0 | 15.3 ± 1.8 | 18.4 ± 1.7 | 19.9 ± 1.6 |
| Urea (mmol/l) | 21.5 ± 2.4 | 19.7 ± 1.7 | 26.0 ± 4.5 | 19.7 ± 1.8 |
| ALAT (U/l) | 75.6 ± 39.7 | 25.0 ± 2.8 | 38.3 ± 7.9 | 73.5 ± 26.1 |
| Alkaline phosphatase (U/l) | 58.2 ± 10.9 | 49.7 ± 3.2 | 74.6 ± 9.5 | 74.6 ± 9.6 |
| Triglycerides (mmol/l) | 0.44 ± 0.08 | 0.54 ± 0.04 | 0.81 ± 0.10 | 1.01 ± 0.18a,b |
Values are mean ± SEM two months after induction of uremia and initiation of high-fat, high-cholesterol diet. ALAT, alanine aminotransferase; apo, apolipoprotein; Lp(a), lipoprotein(a); WT, wild-type.
a
P < 0.05 compared with WT (one way ANOVA).
b
P < 0.05 compared with apo(a) (one way ANOVA).