TABLE 5.

Association of SNPs and haplotypes with CAD in GeneBank

	All Subjects (n = 3031)				Subjects with LDL > 100 mg/dl (n = 1212)
Number of alleles	0	1	2	P	0	1	2	P
rs2048327a	1	1.2 (0.9–1.6)	1.5 (1.0–2.2)	0.04	1	1.2 (0.8–1.8)	1.7 (0.9–3.0)	0.09
rs3127599a	1	1.2 (0.9–1.6)	1.1 (0.7–1.6)	0.32	1	1.5 (1.0–2.2)	0.9 (0.5–1.7)	0.44
rs7767084a	1	1.3 (0.9–1.7)	0.8 (0.4–1.5)	0.40	1	1.2 (0.8–1.9)	0.8 (0.2–2.8)	0.50
rs10755578a	1	1.3 (0.9–1.6)	1.4 (1.0–2.0)	0.04	1	1.1 (0.7–1.6)	1.4 (0.0–2.4)	0.19
CTTGb	1	1.1 (0.9–1.5)	2.2 (0.9–5.2)	0.09	1	1.2 (0.8–1.8)	1.2 (0.4–3.4)	0.46
CCTCb	1	1.3 (0.7–2.7)	*NA	0.39	1	1.9 (0.6–5.8)	*NA	0.23
rs6919346c	1	1.0 (0.8–1.4)	0.5 (0.2–0.9)	0.32	1	0.9 (0.6–1.4)	0.4 (0.1–1.0)	0.15
rs9457925d	1	2.2 (0.9–5.2)	*NA	0.07	1	2.6 (0.8–9.0)	*NA	0.12
rs2292334d	1	1.2 (1.0–1.6)	1.5 (1.0–2.2)	0.03	1	1.2 (0.8–1.7)	1.7 (1.0–3.2)	0.07

Data are shown as OR (95% CI) with adjustment for age and gender.

^*ORs were not calculated for homozygous carriers of these variants since there were only three subjects carrying two alleles.

^aReported by Tregouet et al. (2009).

^bRisk haplotypes of rs2048327, rs3127599, rs7767084, and rs10755578 reported by Tregouet et al. (2009).

^cReported by Ober et al. (2009).

^dPart of ongoing GWAS currently being carried out at the Cleveland Clinic using the Affymetrix 6.0 GeneChip.