Appendix Table 3.

Hazard ratios (95% confidence intervals) of coronary heart disease for continuous use of estrogen-plus-progestin therapy versus no hormone therapy use from different imputation methods for missing proportion of hormone use in a given follow-up year, the Women's Health Initiative randomized trial

	Follow-up period
	Overall (8-year cumulative use)	≤2 years (2-year cumulative use)	>2 years (6-year cumulative use)
All women
Zero	1.78 (1.01, 3.15)	2.29 (1.49, 3.53)	1.39 (0.89, 2.16)
Half	1.62 (0.94, 2.80)	2.34 (1.53, 3.58)	1.29 (0.85, 1.95)
One	1.60 (0.92, 2.79)	2.28 (1.50, 3.46)	1.28 (0.84, 1.96)
Same as previous year	1.58 (0.92, 2.72)	2.33 (1.53, 3.55)	1.27 (0.84, 1.92)
Multiple imputation	1.43 (0.85, 2.42)	2.22 (1.46, 3.38)	1.17 (0.78, 1.76)
Years since menopause
< 10
Zero	0.74 (0.24, 2.30)	1.22 (0.50, 3.00)	0.71 (0.30, 1.70)
Half	0.69 (0.22, 2.17)	1.28 (0.51, 3.18)	0.67 (0.28, 1.62)
One	0.65 (0.21, 2.01)	1.26 (0.50, 3.17)	0.65 (0.28, 1.53)
Same as previous year	0.66 (0.21, 2.04)	1.34 (0.53, 3.36)	0.65 (0.27, 1.56)
Multiple imputation	0.56 (0.18, 1.71)	1.12 (0.46, 2.71)	0.57 (0.24, 1.36)
≥ 10
Zero	2.19 (1.11, 4.32)	2.73 (1.66, 4.50)	1.61 (0.94, 2.77)
Half	2.10 (1.13, 3.88)	2.79 (1.71, 4.56)	1.56 (0.96, 2.53)
One	2.11 (1.12, 3.97)	2.78 (1.72, 4.49)	1.59 (0.97, 2.61)
Same as previous year	2.00 (1.08, 3.71)	2.72 (1.67, 4.43)	1.51 (0.93, 2.45)
Multiple imputation	1.88 (1.04, 3.41)	2.78 (1.73, 4.49)	1.47 (0.91, 2.36)
Age at baseline (years)
50-59
Zero	1.57 (0.60, 4.09)	2.57 (1.10, 6.04)	1.29 (0.61, 2.72)
Half	1.46 (0.56, 3.83)	2.69 (1.13, 6.39)	1.22 (0.57, 2.59)
One	1.48 (0.58, 3.76)	2.57 (1.07, 6.15)	1.23 (0.60, 2.54)
Same as previous year	1.40 (0.55, 3.60)	2.85 (1.20, 6.78)	1.19 (0.57, 2.49)
Multiple imputation	1.20 (0.38, 3.79)	2.23 (0.87, 5.69)	1.04 (0.43, 2.55)
≥ 60
Zero	1.85 (0.97, 3.52)	2.24 (1.37, 3.65)	1.42 (0.86, 2.34)
Half	1.67 (0.92, 3.05)	2.27 (1.40, 3.66)	1.31 (0.83, 2.08)
One	1.64 (0.89, 3.02)	2.22 (1.39, 3.55)	1.30 (0.82, 2.07)
Same as previous year	1.64 (0.90, 2.97)	2.23 (1.39, 3.60)	1.29 (0.82, 2.05)
Multiple imputation	1.50 (0.87, 2.58)	2.23 (1.40, 3.55)	1.21 (0.80, 1.84)