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. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: Cell. 2010 Aug 19;142(5):749–761. doi: 10.1016/j.cell.2010.07.040

Figure 3. The interface between Sema7A and PlexinC1-SemaPSI.

Figure 3

(A) The overall structure of an interacting pair of Sema7A and PlexinC1-SemaPSI protomers, highlighting the structural elements involved in their binding, colored cyan for Sema7A and pink for PlexinC1-SemaPSI.

(B) Closeup view of the interface with Sema7A depicted as ribbons and PlexinC1-SemaPSI in a surface representation, showing how the protruding loop 4c-4d of Sema7A inserts into a groove in PlexinC1 blade 3, and is flanked by the contacts between the Sema7A extrusion helix 2 and the PlexinC1 loop 3b-3c, and the contacts between the blade 3 of Sema7A and the bulged strand 3d of PlexinC1.

(C) The interactions of residues near the obstructed end of the PlexinC1 groove, with Sema7A in chocolate and PlexinC1 in pink.

(D) The interaction between residues of the 4c-4d loop of Sema7A (cyan) and the PlexinC1 groove (pink).

(E) The interaction between the residues of blade 3 of Sema7A (green) and strand 3d of PlexinC1 (pink). Note that residues 218-220 of PlexinC1 comprise a bulge from strand 3d.

The interactions are listed in Table S2. Mutagenesis/binding data on this interface are in Figure S4.