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. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: Cell. 2010 Aug 19;142(5):749–761. doi: 10.1016/j.cell.2010.07.040

Figure 4. The interface between A39R and PlexinC1-SemaPSI.

Figure 4

(A) Structural superposition of the A39R/PlexinC1-SemaPSI and Sema7A/PlexinC1-SemaPSI complexes indicating the closely related docking modes of the viral and mammalian Semaphorins to the PlexinC1 receptor. The complexes have been aligned on the PlexinC1 component in order to visualize the respective overlap of the two different Semaphorins. The A39R is in yellow, Sema7A in cyan.

(B) Closeup view of the interface with A39R depicted as ribbons and PlexinC1-SemaPSI in a surface representation.

(C) The interactions of residues near the obstructed end of the PlexinC1 groove, with A39R in chocolate and PlexinC1-SemaPSI in pink.

(D) The interaction between residues of the 4c-4d loop of A39R (blue) and the PlexinC1 groove (pink).

(E) The interaction between the residues of blade 3 of A39R (green) and strand 3d of PlexinC1-SemaPSI (pink).

The interactions are listed in Table S3.