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. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: Cell. 2010 Aug 19;142(5):749–761. doi: 10.1016/j.cell.2010.07.040

Figure 5. The conformation of the 4c-4d loop of Semaphorins is central for Plexin recognition.

Figure 5

(A), (B), (C) and (D) Stick models of the isolated 4c-4d loops of Sema7A (cyan), A39R (yellow), Sema4D (green), and Sema3A (pink), showing its conserved conformation at the bases (top) and the mid-points of the loops, and variable conformation at the tips of the loops (bottom).

(E) Sequence comparison of the 4c-4d loop of Semaphorins, with the key conserved structural determinants highlighted.

See also Figure S5 for the RGD motif at the base of the Sema7A 4c-4d loop.