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. Author manuscript; available in PMC: 2011 Sep 3.
Published in final edited form as: Cell. 2010 Aug 19;142(5):749–761. doi: 10.1016/j.cell.2010.07.040

Figure 6. Viral mimicry of Sema7A by A39R.

Figure 6

(A) and (B) The respective PlexinC1-binding surfaces of Sema7A (left, cyan) and A39R (right, yellow). The residues mapped at the interface are colored red for acidic residues, blue for basic residues, gray for polar, non-charged residues, and green for apolar residues.

(C), (D) and (E) Mutations of the A39R residues mapped to the Sema7A-PlexinC1 interface abolished or dramatically reduced A39R-PlexinC1 binding.

(F) The different conformation of PlexinC1 Arg222 in binding A39R and Sema7A.

(G) Calorimetric measurement of the binding between A39R and the Arg222Ser mutant of PlexinC1-SemaPSI.

A structural and sequence comparison of Sema7A and A39R is shown in Figure S3.