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Cortical lesions significantly reverse dopamine depletion–induced MSN spine loss. Cortical lesions attenuated spine loss only in the M1-recipient zone (hatched bar) and not in an adjacent territory (stippled bar). Numbers inside each bar indicate the number of animals/group. *P < 0.01 relative to control animals. #P = 0.0008 relative to 6-OHDA-lesioned animals with intact cortex.
