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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Science. 2010 Jun 18;328(5985):1495–1496. doi: 10.1126/science.1192409

Potential dual role of SREBP in metabolic syndrome.

Potential dual role of SREBP in metabolic syndrome

In obese subjects with metabolic syndrome, insulin resistance leads to elevated insulin, which activates transcription of SREBP-1c in the liver. This leads to increased VLDL triglycerides and decreased HDL cholesterol in the blood. miR-33b is encoded in intron 17 (red); exons are in blue.