Effect of unilateral injection of l-SOP (A,C,E) or l-AP4 (B,D,F) in the SNpr on reversal of akinesia in the reserpine-treated rat. (A,B) Time-course of locomotor activity induced by the maximally effective dose of l-SOP or l-AP4. Data are mean ± SEM (n = 6); ***P < 0.001 significantly different from vehicle. (C,D) Effect of l-SOP or l-AP4 on rotational activity over 60 min. Data are mean ± SEM (n = 6). In (C), *P < 0.05 and **P < 0.01 significantly different from vehicle, #P < 0.05 significantly different from 250 nmol dose. In (D), ***P < 0.001 significantly different from vehicle and 3 nmol: #P < 0.05 significantly different from 30 and 100 nmol. (E,F) Effect of pretreatment with CPPG (75 nmol) on the rotational responses to l-SOP (750 nmol) or l-AP4 (300 nmol). Data are mean ± SEM (n = 6). ***P < 0.001 significantly different from vehicle pretreatment.