Table 2.
PON1 genotype and allelic variants of patients with different types of brain tumor.
| Astrocytoma (N = 44, 88 chromosomes) | OR (95% CI); P | Meningioma (N = 29, 58 chromosomes) | OR (95% CI); P | |
|---|---|---|---|---|
| GENOTYPES | ||||
| PON1 55 Leu/Leu | 8 (18.2) [6.8-29.6] | 1.07 (0.47-2.43); 0.8851 | 3 (10.3) [0-21.4] | 0.55 (0.17-1.81); 0.3451 |
| PON1 55 Leu/Met | 19 (43.2) [28.5-57.8] | -- | 13 (44.8) [26.7-62.9] | -- |
| PON1 55 Met/Met | 17 (38.6) [24.2-53.0] | 0.94 (0.49-1.82); 0.8662 | 13 (44.8) [26.7-62.9] | 1.22 (0.57-2.62); 0.6192 |
| PON1 192 Gln/Gln | 19 (43.2) [28.5-57.8] | 0.77 (0.41-1.48); 0.4421 | 12 (41.4) [23.5-59.3] | 0.72 (0.33-1.56); 0.4091 |
| PON1 192 Gln/Arg | 20 (45.5) [30.7-60.2] | -- | 13 (44.8) [26.7-62.9] | -- |
| PON1 192 Arg/Arg | 5 (11.4) [2.0-20.7] | 1.15 (0.43-3.14); 0.7862 | 4 (13.8) [1.2-26.3] | 1.44 (0.48-4.34); 0.5312 |
| ALLELES | ||||
| PON1 55 Leu | 35 (39.8) [29.5-50.0] | 1.05 (0.66-1.67); 0.8423 | 19 (32.8) [20.7-44.8] | 0.77 (0.44-1.38); 0.3863 |
| PON1 55 Met | 53 (60.2) [50.0-70.5] | -- | 39 (67.2) [55.2-79.3] | -- |
| PON1 192 Gln | 58 (65.9) [56.0-75.8] | -- | 37 (63.8) [51.4-76.2] | -- |
| PON1 192 Arg | 30 (34.1) [24.2-44.0] | 1.19 (0.74-1.94); 0.4743 | 21 (36.2) [23.8-48.6] | 1.31 (0.74-2.31); 0.3553 |
The values in each cell represent: number (percentage) and [95% confidence intervals]. 1The OR was calculated by using the dominant model. 2The OR was calculated by using the recessive model. 3The OR was calculated by using the allelic model. Test for trend with the number of variant alleles: Astrocytoma PON1 55 Leu/Met: H = 0.0360 df = 1 p = 0.8496; PON1 192 Gln/Arg: H = 0.5537 df = 1 p = 0.4568. Meningioma PON1 55 Leu/Met: H = 0.5987 df = 1 p = 0.4391; PON1 192 Gln/Arg: H = 0.8057 df = 1 p = 0.3694.