Figure 3.

Locomotor activity (crossovers; Upper) and stereotyped behavior (sniffing and rearing; Lower) after i.p. injection of cocaine (15 mg/kg) after immunization with GNC92H2. The figure shows the response to postimmunization cocaine challenge on the 3rd (a), 7th (b), and 12th (c) day after the passive immunization treatment. Upper values represent means ± SEM of 16 animals (n = 8). *, P < 0.01; ANOVA, significant difference between groups. Lower data represent the percentage of incidence of the observed behavior. *, P < 0.05.