Table 1. Development of liver tumors in Mcl-1Δhep mice.
At the age of 8 and 12 months, no tumors were detected in wild-type or heterozygous Mcl-1flox/wtmice. >50% of the Mcl-1Δhep mice revealed up to 14 macroscopically detectable tumor nodules / liver.
| Genotype | mice (n) | incidence of liver tumors |
number of tumor nodules (range) |
|---|---|---|---|
| wilde-type | 9 | 0/9 | 0 |
| Mcl-1flox/wt | 15 | 0/15 | 0 |
| Mcl-1Δhep | 21 | 11/21 | 1-14 |