Figure 2.
Chemical structures and acronyms for the tridentate SHAL (upper right) DvLPLLCtPCbPLDo; (dabsyl-l-valine PEG lysine lysine 3-(2-([3-chloro-5-trifluoromethyl)-2-pyridinyl]oxy)-anilino)-3-oxopropanionic acid PEG 4-[4-(4-chlorobenzyl)piperazino]-3-nitrobenzenecarboxylic acid lysine-DOTA having the Ct ligand (upper left insert); and the dimeric, tridentate SHAL (lower) (DvLPLLCtPCbPPP)2LLDo; ((dabsyl-l-valine PEG lysine lysine 3-(2-([3-chloro-5-trifluoromethyl)-2-pyridinyl]oxy)-anilino)-3-oxopropanionic acid PEG 4-[4-(4-chlorobenzyl)piperazino]-3-nitrobenzenecarboxylic acid PEG PEG PEG)2 lysine lysine-DOTA. (Analog-biotinylated SHALs differ only with respect to substitution of biotin for the DOTA chelate, upper right of each SHAL.)