Figure 4.

Cell-associated SHAL uptake increased as SHAL in the media was increased, even over 1000 ng (A). SHALs containing the Ct ligand residualized in expressing cells (B), and SHAL uptake was greater than the surface-membrane HLA-DR10 of Raji cells. As manifested by the differing behaviors of SHALs having and lacking Ct ligand in expressing and nonexpressing cells, residualization was mediated by HLA-DR10 and the Ct ligand. Data are shown for Raji cells after subtracting that for CEM cells (B).