Table 2.
Baseline physical function, fatigue, pain and productivity in RAPID trials (ITT population)
| Characteristics | RAPID 1 (N = 982) | RAPID 2 (N = 619) |
|---|---|---|
| HAQ-DI (0–3.0)a, mean (s.d.) | 1.7 (0.6) | 1.6 (0.6) |
| FAS (0–10)b, mean (s.d.) | 6.5 (2.0) | 6.5 (1.9) |
| Pain VAS (0–100)c, mean (s.d.) | 63.1 (18.9) | 60.9 (20.2) |
| SF-36 | ||
| PCS summary score (0–50), mean (s.d.) | 30.8 (6.5) | 30.9 (6.2) |
| Physical function domain score (0–100), mean (s.d.) | 32.9 (21.1) | 32.3 (20.3) |
| VT domain score (0–100), mean (s.d.) | 35.3 (18.2) | 37.0 (17.7) |
| BP domain score (0–100), mean (s.d.) | 29.5 (15.4) | 30.2 (15.0) |
| WPS-RA, mean (s.d.) | ||
| Days of paid work missed due to RA per monthd | 3.9 (8.0) | 3.3 (6.8) |
| Days with productivity at work reduced by ≥50% due to RA per monthe | 7.1 (8.5) | 8.8 (8.6) |
| Rate of RA interference on work productivity per monthf | 5.2 (2.6) | 5.5 (2.3) |
| Days of household work missed due to RA per monthd | 8.1 (8.5) | 6.9 (7.4) |
| Days with household productivity reduced by ≥50% due to RA per monthe | 10.4 (8.4) | 10.8 (8.2) |
| Days of missed family, social or leisure activities due to RA per monthd | 6.1 (8.7) | 5.0 (7.5) |
| Days with outside hired help per monthd | 5.4 (9.0) | 5.0 (8.7) |
| Rate of RA interference on household work productivity per monthf | 6.2 (2.3) | 5.9 (2.2) |
aHAQ-DI scores range from 0 to 3, with lower scores indicating improvements in physical function. bFAS scores range from 0 to 10, with lower scores indicating less fatigue. cScores for patient’s assessment of arthritis pain range from 0 to 100 mm, with lower scores indicating relief in arthritis pain. dRange is 0–30 (in past month). eRange is 0–30 (in past month) and does not include days counted in previous question. fRange is 0–10, where 0 indicates no interference and 10 indicates complete interference.