Table 4.

Mean changes in productivity from baseline to Week 12 by SF-36 responder status (observed data, pooled RAPID 1 and 2, CZP 200 + 400 mg groups)

	SF-36 PCS (MCID ≥2.5)		SF-36 PF domain (MCID ≥5.0)		SF-36 VT domain (MCID ≥5.0)		SF-36 BP domain (MCID ≥5.0)
WPS-RA, mean change from baseline to Week 12	Responder	Non- responder	Responder	Non- responder	Responder	Non- responder	Responder	Non- responder
Employed patients	(n = 201)	(n = 121)	(n = 194)	(n = 128)	(n = 180)	(n = 142)	(n = 245)	(n = 77)
Absenteeism (paid work days missed) due to RA	−2.2	−1.7	−2.2	−1.8	−2.2	−1.8	−2.2	−1.4
Presenteeism (days with productivity at work reduced by ≥50%) due to RA	−5.6	−4.1	−5.9*	−3.8	−6.6**	−3.1	−5.6*	−3.2
Rate of RA interference on work productivity	−2.5***	−1.5	−2.6***	−1.4	−2.8***	−1.3	−2.4**	−1.3
All patients	(n = 469)	(n = 332)	(n = 436)	(n = 365)	(n = 455)	(n = 346)	(n = 584)	(n = 217)
Days of household work missed due to RA	−4.6	−3.8	−5.1***	−3.3	−5.2***	−3.1	−5.0***	−2.2
Days with household productivity reduced by ≥50% due to RA	−6.0**	−4.2	−6.1**	−4.3	−5.9*	−4.5	−5.6	−4.4
Days of missed family, social or leisure activities due to RA	−3.6	−3.3	−4.1*	−2.8	−4.2**	−2.5	−3.8*	−2.5
Days with outside hired help	−3.0	−2.2	−3.2*	−2.1	−3.4**	−1.7	−3.2***	−1.3
Rate of RA interference on household work productivity	−2.6***	−1.4	−2.6***	−1.4	−2.6***	−1.3	−2.5***	−1.0

Response is defined as change from baseline to Week 12 ≥MCID (in absolute value), non-response is defined as mean change from baseline to Week 12 <MCID. n represents number of subjects with non-missing WPS-RA, considered in the analysis.

*P≤0.05 vs non-responders; **P≤0.01 vs non-responders; ***P≤0.001 vs non-responders.