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. 2010 Jun 29;49(10):1867–1877. doi: 10.1093/rheumatology/keq151

Fig. 1.

Fig. 1

Distinct cellular cytotoxic, humoral and chemotactic patterns identified in IIMs. Levels of 24 serum biomarkers were measured simultaneously using a biometric multiplex assay from serum of subsets of patients with IIMs, and unaffected control individuals. (A) Cellular cytotoxic patterns identified elevations of IL-1β, IL-7, IL-12, IL-17, IFN-α in DM, IL-17, GM-CSF, IFN-α, IL-1Rα, IL-7 in PM, IL-1β, IL-12, GM-CSF, IFN-α and IL-1Rα in JDM, and IL-1β, IL-17, GM-CSF, IFN-α, IL-1Rα in CAM. (B) Humoral patterns identified elevations of IL-6 and IL-10 in DM, and IL-10 in PM, JDM and CAM. (C) Chemotactic patterns identified elevations of CCL2, CCL3, CCL4, CCL11, CXCL8 and CXCL10 in DM, CCL11, CCL3 and CCL4 in PM, CCL11, CCL3, CCL4 and CXCL10 in JDM, and CCL11, CCL3, CCL4 and CXCL10 in CAM. Patients with overlap diseases had a mixed-diverse cytokine profile with significant elevations of IL-1β, IL-12, GM-CSF, IL-1Rα, IL-7, IL-6, IL-10, IL-13, CCL3, CCL4 and CXCL10. Cytokines significantly elevated in groups relative to controls are denoted with an asterisk (*P < 0.05 and **P < 0.001).