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. 2010 Jun 26;49(10):1852–1861. doi: 10.1093/rheumatology/keq188

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© The Author(s) 2010. Published by Oxford University Press on behalf of The British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Inflammatory cells in subchondral bone spaces and associated vascular channels. (A) CD3-positive lymphocytes (black) within fibrovascular tissue occupying subchondral bone spaces in RA and OA, but not in the fatty marrow of a PM control. Inset: subchondral bone space showing CD3-positive lymphocytes (arrows). Bo: bone; CC: calcified cartilage; NCC: non-calcified cartilage; broken line: tidemark. (B) CD68-positive cells (black) in RA, PM controls and OA. Mononuclear CD68-positive cells resembled macrophages and were localized either at the bone surface, or deeper within the subchondral bone space. Multinucleated CD68-positive cells localized at the bone surface (insets) resembled osteoclasts. Tissue morphology is revealed by combined transmitted and fluorescent light (blue/white: cartilage, bone; yellow: background). Scale bar = 100 microns.