Table 1.

Strategies for Effective Drug Delivery into the Mitochondrial Matrix

Low molecular weight SOD mimetics	Mitochondrial membrane potential-dependent delivery system (delocalized cations)	Dequalinium liposome-based delivery system	Amino acid and peptide-based delivery systems
EUK-8 and EUK-134 (369)	Rhodamine 123-conjugated drugs (28, 29, 262) Cisplatin and Mastoparan (28, 136, 262, 276, 335, 358, 563)	Plasmid DNA (603, 631)	Amino acid-based Glutathione choline ester (519) NAC choline ester (28, 519)
Manganese porphyrins (90, 99, 105, 534, 542): AEOL 10150 MnTBAP MnTPyP MnIII TE-2-PyP5+	Methyltriphenylphosphonium (TPP+) conjugated drugs (28, 29, 85, 393, 453, 498, 527, 584, 619): MitoQ MitoVitE Ubiquinol Mitotempol MitoPBN	Small molecules (anti-cancer drugs) (4, 28, 29, 72, 131, 136, 262, 276, 339, 393, 424, 468, 603, 631): CD437 Paclitaxel Verteporfin	Small peptides and proteins (101, 123, 136, 212, 262, 393, 465, 507, 551, 553, 554, 574): SS tetrapeptides (antioxidants) SS 31 SS 01 TAT proteins for delivery of proteins to mitochondria