Figure 2. Serum stability profiles of the LfcinB- and Combi-based peptides. Relative peptide concentrations were determined by integration of the A215 peaks from RP-HPLC chromatograms.

A) Linear LfcinB hexamers showing individual and combined effects of C-terminal amidation and N-terminal acetylation, B) Linear Combi hexamers with end caps C) Linear and cyclized LfcinB peptides comparing the end-to-end disulfide bridging and head-to-tail backbone cyclization strategies to different sized peptides, and D) cyclized Combi peptides. Assays were performed in triplicate.