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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Dev Biol. 2009 Dec 16;338(2):270–279. doi: 10.1016/j.ydbio.2009.12.008

Figure 3.

Figure 3

Severe ileitis and colitis in germline Agr2−/− mice. (A) H&E staining reveals severe acute ileitis, with a dense, primarily neutrophilic infiltrate in the lamina propria and submucosa. Inset reveals neutrophils surrounding hypertrophied Paneth cells. (B) Acute colitis in the proximal colon, with loss of goblet cells, crypt elongation, and infiltrating neutrophils (inset). (C) Florid lymphoid hyperplasia of ileal Peyer’s patches, with multinucleated giant cells (white arrows). (D) Multinucleated giant cells suggestive of granulomatous inflammation in interfollicular zones are seen at higher power (inset, lower right).