TABLE 3.
UNIVARIATE AND MULTIVARIATE ANALYSES OF THE RELATIONSHIP BETWEEN MIRNA EXPRESSION AND DISEASE-FREE SURVIVAL IN ESOPHAGEAL ADENOCARCINOMA PATIENTS
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| miRNA | Frequency (N) |
HR | 95% CI |
p value |
HR | 95% CI |
p value |
| Let-7g | − 37 | 1.00 | 1.00 | ||||
| + 62 | 0.77 | 0.50-1.19 | 0.24 | 0.64 | 0.33-1.23 | 0.18 | |
| miR-9 | − 11 | 1.00 | 1.00 | ||||
| + 88 | 0.75 | 0.40-1.41 | 0.37 | 0.45 | 0.18-1.12 | 0.086 | |
| miR-16-2 | − 52 | 1.00 | 1.00 | ||||
| + 47 | 1.60 | 1.05-2.44 | 0.028 | 0.88 | 0.47-1.64 | 0.69 | |
| miR-20 | − 16 | 1.00 | 1.00 | ||||
| + 83 | 1.09 | 0.60-1.98 | 0.77 | 0.66 | 0.24-1.81 | 0.42 | |
| miR-21 | − 11 | 1.00 | 1.00 | ||||
| + 88 | 1.62 | 0.81-3.26 | 0.18 | 0.96 | 0.37-2.48 | 0.93 | |
| miR-30e | − 25 | 1.00 | 1.00 | ||||
| + 74 | 2.21 | 1.31-3.76 | 0.003 | 2.53 | 1.13-5.67 | 0.024 | |
| miR-34a | − 58 | 1.00 | 1.00 | ||||
| + 41 | 0.74 | 0.48-1.14 | 0.17 | 0.72 | 0.43-1.22 | 0.22 | |
| miR-126 | − 46 | 1.00 | 1.00 | ||||
| + 53 | 1.37 | 0.89-2.11 | 0.15 | 0.83 | 0.48-1.44 | 0.51 | |
| miR-195p | − 37 | 1.00 | 1.00 | ||||
| + 62 | 1.52 | 0.97-2.39 | 0.067 | 2.05 | 1.08-3.90 | 0.029 | |
| miR-200a | − 46 | 1.00 | 1.00 | ||||
| + 53 | 1.51 | 0.98-2.31 | 0.06 | 1.30 | 0.69-2.42 | 0.42 | |